Quantitative mechanisms of DNA damage sensing and signaling

Radiation track and DNA damage

Editorial: Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair, and Replication in Plants

Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy, Department of Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi, India, 3 Plant Breeding, Genetics and Biotechnology Division, International Rice Research Institute, Los Baños, Philippines, 4 Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan...

DNA Damage Response and Repair Mechanisms

The brochure accompanies the symposium and features the consortium and its members. Support by the European Community is gratefully acknowledged.

Oxidative DNA damage: mechanisms, mutation, and disease.

Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to th...

Measuring of DNA Damage by Quantitative PCR

PCR is an in vitro method of nucleic acid synthesis by which a particular segment of DNA can be specifically replicated. It involves two oligonucleotide primer that flank the DNA fragment to be amplified and repeated cycles of heat denaturation of the DNA, annealing of the primers to their complementary sequences, and extension of the annealed primers with DNA polymerase. Successive cycles of a...